ea0045p57 | Miscellaneous/other | BSPED2016
Estebanez Maria Salomon
, Craigie Ross
, Han Bing
, Mal Walaa
, Mohammed Zainab
, Newbould Melanie
, Cheeseman Edmund
, Bitetti Stefania
, Rigby Lindsey
, Banerjee Indi
, Dunne Mark
Introduction: Congenital Hyperinsulinism (CHI) is a heterogeneous condition caused by dysregulation of insulin secretion. Paternally inherited mutations in ABCC8 or KCNJ11 are associated with loss of the maternal 11p15 allele in focal CHI (CHI-F). CHI-F can be curative after selective lesionectomy. However, histological heterogeneity within the CHI-F lesions has not been previously reported. We aimed to examine the diversity in focal lesions and correlate wit...